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鍖诲闄㈢邯瀹惰懙鍥㈤槦寤虹珛鏂板瀷鍑忔暟鍒嗚鑽у厜鎶ュ憡绯荤粺涓︽彮绀虹敓娈栫粏鑳炰笌鎬ц吅浣撶粏鑳炵殑浜掍綔鏈哄埗2021-09-26
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鈥滃皬灏惧反鈥濈殑鏂版姄娉-鍖诲闄㈡潕娴锋稕缁勬彮绀篜HF14璇嗗埆缁勮泲鐧紿3鏂版ā寮2021-09-09
缁勮泲鐧戒慨楗版槸琛ㄨ閬椾紶璋冩帶閲嶈鏈哄埗锛屽湪澶嶅埗銆佽浆褰曞拰淇绛変互鏌撹壊璐ㄤ负妯℃澘鐨勭粏鑳炶繃绋嬩腑鍙戞尌鐫鑷冲叧閲嶈鐨勪綔鐢ㄣ傚弬涓庣粍铔嬬櫧璇嗗埆鐨勫洜瀛愯褰㈣薄鍦扮О浣滅粍铔嬬櫧鈥滈槄璇诲櫒鈥濓紙reader锛夈傝嚜1999骞寸編鍥借タ濂堝北鍖诲闄㈢殑鍛ㄦ槑鏄庯紙Ming-Ming Zhou锛夊疄楠屽鍙戠幇绗竴绫荤粍铔嬬櫧闃呰鍣ㄢ旀捍鍩燂紙Bromodomain锛変互鏉ワ紝鍙戠幇鏂板瀷鈥滅粍铔嬬櫧-闃呰鍣ㄢ濊瘑鍒骞舵帰绌跺叾鐢熺墿鍔熻兘鎴愪负琛ㄨ閬椾紶瀛﹂鍩熺殑涓涓爺绌剁儹鐐广2021骞9鏈7鏃ワ紝娓呭崕澶у鍖诲闄㈡潕娴锋稕璇鹃缁勪簬銆奛ucle...
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娓呭崕澶у閮鎵嶈棰樼粍鍦ㄣ婄缁忓厓銆嬶紙Neuron锛夊彂鏂囨姤閬撳伐浣滆蹇嗙殑鐢熸垚鏈哄埗2021-09-02
2021骞8鏈31鏃ワ紝娓呭崕澶у鍖诲闄佹竻鍗庯紞鍖楀ぇ鐢熷懡绉戝鑱斿悎涓績銆両DG/楹︽垐鏂囪剳绉戝鐮旂┒闄㈤儹澧炴墠璇鹃缁勫湪绁炵粡绉戝棰嗗煙鏉冨▉瀛︽湳鏈熷垔銆婄缁忓厓銆嬶紙Neuron锛夊湪绾垮彂琛ㄩ涓恒婄毊灞-鍩哄簳鑺-涓樿剳-鐨眰閫氶亾鍦ㄧ煭鏃惰蹇嗕腑鐨勪綔鐢ㄣ嬶紙A Cortico-basal ganglia-thalamo-cortical Channel Underlying Short-term Memory锛夌殑鐮旂┒璁烘枃锛屾彮绀虹毊灞傘佸熀搴曡妭鍜屼笜鑴戝舰鎴愮殑澶氳剳鍖虹綉缁滃浣曚績杩涘伐浣滆蹇嗭紙鐨勭煭鏃惰蹇嗘垚鍒嗭級鐨勫舰鎴愩傚伐浣滆蹇嗗皢淇℃伅鐭殏鍦板瓨鍌ㄥ湪...
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绁佹捣璇鹃缁勬彮绀築CL6璋冩帶婊ゆ场杈呭姪T缁嗚優鐨勭粏鑳炲厤鐤鏂版満鍒2021-08-31
2021骞8鏈30鏃ワ紝娓呭崕澶у鍖诲闄㈢娴疯棰樼粍鍦ㄣ奍mmunity銆嬫湡鍒婁笂鍦ㄧ嚎鍙戣〃浜嗛涓築CL6 controls contact-dependent help delivery during follicular T-B interactions (BCL6鎺у埗婊ゆ场T-B缁嗚優闂存帴瑙︿緷璧栨ц緟鍔╀俊鍙蜂紶閫)鐨勭爺绌惰鏂囥傝鐮旂┒鍙戠幇BCL6鎺у埗婊ゆ场杈呭姪鎬缁嗚優浜х敓閽欎俊鍙疯浆瀵肩殑鑳藉姏锛屼粠鑰屾帶鍒跺叾涓嶣缁嗚優涔嬮棿鐨勭獊瑙﹂粡闄勭浉浜掍綔鐢紝杩涜屽彲閫氳繃闈濼缁嗚優鑷富鐨勬柟寮忕淮鎸佹护娉¤緟鍔╂缁嗚優鐗瑰緛銆傛姉浣撴槸鏈轰綋鎶垫姉鐥呭師浣撴劅鏌撶殑閲嶈鍏嶇柅鏈哄埗...
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鍖诲闄㈠惔鍔辫棰樼粍鎻ず璋冩帶鑲虹氦缁村寲鍙戠梾杩涚▼鐨勬柊鏈哄埗2021-08-31
2021骞8鏈27鏃ワ紝娓呭崕澶у鍖诲闄㈠惔鍔辫棰樼粍鍦ㄣ奝roceedings of the National Academy of Sciences銆嬶紙缇庡浗绉戝闄㈤櫌鎶 锛夋潅蹇楀湪绾垮彂琛ㄩ涓衡淟RRK2 plays essential roles in maintaining lung homeostasis and preventing the development of pulmonary fibrosis鈥濓紙LRRK2鍦ㄨ偤閮ㄧǔ鎬佺淮鎸佸強鑲虹氦缁村寲鍙戝睍涓彂鎸ュ叧閿綔鐢級鐨勭爺绌惰鏂囥傝鐮旂┒鍒╃敤鍗氳幈闇夌礌璇卞鐨勮偤绾ょ淮鍖栧皬榧犳ā鍨嬪拰澶氱鎶鏈墜娈碉紝鎻ず浜哛IPK瀹舵棌鎴愬憳LRRK2鍦ㄧ淮鎸佽偤缁勭粐...
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寮犲浼/甯堟槑纾/鏉庡┓濠/闄堥槼鍥㈤槦寮鍙戝嚭 瀹氶噺娴嬪畾鐢熺悊鏉′欢涓嬫煋鑹茶川鐩稿叧铔嬬櫧鐩稿垎绂荤壒鎬х殑鏂版柟娉2021-08-23
缁嗚優鏍镐富瑕佺敱DNA銆丷NA鍜岃泲鐧借川绛夋垚鍒嗙粍鎴愶紝鏄熀鍥犲瓨鍌ㄣ佸鍒朵笌璋冩帶鐨勪腑蹇冦傚湪缁嗚優鏍稿唴锛岃泲鐧借川绛夌敓鐗╁ぇ鍒嗗瓙閫氳繃娑-娑茬浉鍒嗙锛坙iquid-liquid phase separation, LLPS锛夊舰鎴愮敓鐗╁垎瀛愬嚌鑱氫綋锛屽凡缁忚鎶ラ亾涓庡熀鍥犺〃杈1銆佹煋鑹茶川楂樼骇缁撴瀯2绛夌揣瀵嗙浉鍏炽傜劧鑰岋紝鐩墠閴村畾涓庤瘎浼拌泲鐧界浉鍒嗙鐗规т富瑕佷緷璧栦簬浣撳唴澶栧嚌鑱氫綋褰㈡併佸厜婕傜櫧鎭㈠瀹為獙绛夊畾鎬ф垨浣庨氶噺鏂规硶锛屽浣曠郴缁熸у湴銆佸畾閲忔祴瀹氱敓鐞嗘潯浠朵笅鏌撹壊璐ㄧ浉鍏宠泲鐧界浉鍒嗙鐗规э紝鏄鍩熷唴浜熷緟瑙ｅ喅...
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鍖诲闄㈠垬闈欒棰樼粍鍙戞槑娑叉侀噾灞炵鎬ф姄鎵嬶細鍙搷鎺т换鎰忓舰鐘堕潪纾佹х墿浣2021-08-20
瀹炴椂銆佺簿鍑嗐侀潪鎺ヨЕ寮忕殑鎺у埗鎵嬫鍦ㄥ尰鐤楄緟鍔╀笌鏁戞姢锛屽姩妞嶇墿鐢熺墿鍒跺搧鎿嶆帶锛屼互鍙婂啗浜嬪拰宸ヤ笟鎶撴墜绛変紬澶氶鍩熷叿鏈夊箍娉涚殑搴旂敤浠峰笺傚湪鍚勭鎺у埗鎵嬫涓紝纾佸満浣滀负涓绉嶉鍏峰墠鏅殑鎺у埗閫斿緞婊¤冻浠ヤ笂鐨勬妧鏈姹傘傜劧鑰岀粷澶ч儴鍒嗗姩妞嶇墿锛岀敓鐗╁埗鍝侊紝鐜荤拑銆佺焊寮犮侀摐绛夐潪纾佹х墿浣撻毦浠ヨ纾佸満鎿嶆帶銆傚洜姝わ紝濡備綍閫氳繃纾佸満鍙嗘搷鎺ч潪纾佹х墿浣撳叿鏈夐噸瑕佺殑绉戝鐮旂┒鎰忎箟鍜屽伐涓氬簲鐢ㄤ环鍊笺傚彲鐩存帴鎺у埗绌烘皵涓鍦虹殑鈥滀竾纾佺帇鈥濇浘鍦ㄤ互寰鐨勭骞荤數褰变腑琚瀯鎯冲嚭鏉ャ傜幇...
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娓呭崕澶у鍖诲闄㈠惔鍔卞疄楠屽鍒涚珛浣撳璇卞鑲烘场宸ㄥ櫖缁嗚優鍒嗗寲鍙婃墿澧炵殑鏂版柟娉2021-08-20
2021骞8鏈16鏃ワ紝娓呭崕澶у鍖诲闄㈠惔鍔辫棰樼粍鍦ㄣ奣he Journal of Immunology銆嬫潅蹇楀湪绾垮彂琛ㄩ涓衡淒evelopment of an Optimized Culture System for Generating Mouse Alveolar Macrophage鈥搇ike Cells鈥濈殑鐮旂┒璁烘枃銆傝鐮旂┒棣栨鍒╃敤缁嗚優鍥犲瓙GM-CSF鍜孴GF-尾浠ュ強PPAR-纬婵鍔ㄥ墏rosiglitazone鍦ㄤ綋澶栨瀯寤鸿偤娉″法鍣粏鑳炴牱缁嗚優锛圓M-like cells锛夌殑鍩瑰吇浣撶郴锛屼负鐮旂┒鑲烘场宸ㄥ櫖缁嗚優鍙戣偛鍜屽姛鑳芥彁渚涗簡閲嶈宸ュ叿銆傝偤娉″法鍣粏鑳炴槸鑲洪儴涓昏鐨勫浐鏈夊厤鐤...
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寮犳灄鐞/寮犳斂/鐜嬫柊娉/闄堝織浼/鐜嬩綉鏄ュ悎浣滈槓鏄庝笉鍚屾柊鍐犳偅鑰呬綋鍐呬骇鐢熺殑鍏叡鎶椾綋鍙婂彈鐥呮瘨绐佸彉鐨勫奖鍝2021-07-16
2021骞7鏈9鏃ワ紝娓呭崕澶у鍖诲闄㈠紶鏋楃惁鏁欐巿銆佸浗瀹舵劅鏌撴х柧鐥呬复搴婂尰瀛︾爺绌朵腑蹇冿紙娣卞湷甯傜涓変汉姘戝尰闄/鍗楁柟绉戞妧澶у绗簩闄勫睘鍖婚櫌锛夊紶鏀挎暀鎺堛佺敓鍛界瀛﹀闄笌鍖椾含甯傜粨鏋勭敓鐗╁楂樼簿灏栧垱鏂颁腑蹇冪帇鏂版硥鏁欐巿銆侀娓ぇ瀛﹀尰瀛﹂櫌闄堝織浼熸暀鎺堜互鍙婁腑鍥介鍝佽嵂鍝佹瀹氱爺绌堕櫌鐜嬩綉鏄ョ爺绌跺憳鍚堜綔锛屽湪銆婅嚜鐒堕氳銆嬶紙Nature Communications锛夋潅蹇楀彂琛ㄩ涓衡滄姉鏂板啝鐥呮瘨IGHV3-53/3-66鍏叡鎶椾綋鐨勫己鏁堜腑鍜屾椿鎬у強鍏跺湪鏂板啝鍒虹獊铔嬬櫧涓婂叡鍚岀殑閫冮哥獊鍙樹綅鐐光濓紙Potent...
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寮犳灄鐞/鍛ㄤ笢鏄/褰皬蹇/闄堝織浼熷悎浣滅爺鍙戞柊鍨嬪啝鐘剁梾姣掔柅鑻2021-07-13
2021骞6鏈28鏃ワ紝娓呭崕澶у鍖诲闄㈠紶鏋楃惁鏁欐巿銆佸ぉ娲ュ尰绉戝ぇ瀛﹀懆涓滄槑鏁欐巿鐮旂┒鍥㈤槦鍦‵rontiers in Immunology鏉傚織鍦ㄧ嚎鍙戣〃棰樹负Single-Dose Immunization With a Chimpanzee Adenovirus-Based Vaccine Induces Sustained and Protective Immunity Against SARS-CoV-2 Infection锛堝崟娆″厤鐤粦鐚╃尒鑵虹梾姣掕浇浣撶柅鑻楁湁鏁堣瀵间骇鐢熼拡瀵规柊鍨嬪啝鐘剁梾姣掔殑闀挎湡淇濇姢鎬у厤鐤弽搴旓級鐮旂┒璁烘枃銆傝鐮旂┒鍒╃敤绋鏈夐粦鐚╃尒鑵虹梾姣扐dC68涓鸿浇浣擄紝鐮斿彂浜嗕竴绉嶉拡瀵笴OVI...