2018Äê7ÔÂ10ÈÕ£¬1xbetÍøÒ³°æÕÅÁÖçùºÍÉúÃüѧԺÍõÐÂȪÁ½¸ö¿ÎÌâ×éºÏ×÷ÔÚÃÀ¹ú¡¶Ï¸°û¡·ÔÓÖ¾Æìϵġ¶Ï¸°û±¨¸æ¡·£¨Cell Reports£©·¢±íÌâΪ¡± Structural definition of a unique neutralization epitope on the receptor-binding domain of MERS-CoV spike glycoprotein¡±µÄÑо¿ÂÛÎÄ¡£¸ÃÑо¿½âÎöÁËÖж«ºôÎüµÀ×ÛºÏÕ÷¹Ú×´²¡¶¾£¨Middle East respiratory syndrome coronavirus, MERS-CoV£©¿¹ÌåMERS-4ÓëÊÜÌå½áºÏÇøÓò£¨Receptor Binding Domain, RBD£©µÄ½á¹¹£¬½ÒʾÁËÆä¶Àµ½µÄ¿¹²¡¶¾»úÖÆ¡£
MERS-CoVÊÇ2012ÄêÔÚÖж«µØÇøÊ×ÏÈ·¢ÏÖµÄÒ»ÖÖÐÂÐ͹Ú×´²¡¶¾£¬Óë2003Äê·¢ÏÖµÄÑÏÖØ¼±ÐÔºôÎüµÀ×ÛºÏÕ÷¹Ú×´²¡¶¾£¨SARS-CoV£©Í¬ÊôÓڦ¹Ú×´²¡¶¾¡£MERS-CoVÄܹ»Òý·¢ÑÏÖØµÄÈËÀàºôÎüϵͳ¼²²¡£¬ÆäÖÂËÀÂʸߴï36%£¬Ä¿Ç°ÉÐÎÞÕë¶Ô¸Ã²¡¶¾µÄÔ¤·ÀÐÔÒßÃçºÍÌØÐ§µÄÖÎÁÆÊֶΡ£´Ó2012ÄêÖÁ½ñ£¬ÕÅÁÖçùºÍÍõÐÂȪÁ½¸ö¿ÎÌâ×éͨÁ¦ºÏ×÷£¬ÔÚMERS-CoVÏà¹ØµÄÑо¿ÖÐÈ¡µÃÁËһϵÁеÄÍ»³ö³É¹û¡£Á½¸ö¿ÎÌâ×鹲ͬ½âÎöÁËMERS-CoV RBDÓëÆäÊÜÌåµÄ½á¹¹£¨Wang, N. et al. Structure of MERS-CoV spike receptor-binding domain complexed with human receptor DPP4. Cell research 23, 986-993, doi:10.1038/cr.2013.92 (2013)£©£¬¹²Í¬·ÖÀëºÍ¼ø¶¨Á˸ßЧ¿¹MERS-CoVÈËÔ´µ¥¿Ë¡¿¹Ìå £¨MERS-4ºÍMERS-27£©£¨Jiang, L. et al. Potent neutralization of MERS-CoV by human neutralizing monoclonal antibodies to the viral spike glycoprotein. Science translational medicine 6, 234ra259, doi:10.1126/scitranslmed.3008140 (2014)£©£¬²¢ÐÁ¦¶ÔÆäÖÐÒ»¸ö¿¹Ì壨MERS-27£©µÄ±íλÒÔ¼°ÖкͻúÖÆ½øÐÐÑо¿£¨Yu, X. et al. Structural basis for the neutralization of MERS-CoV by a human monoclonal antibody MERS-27. Scientific reports 5, 13133, doi:10.1038/srep13133 (2015)£©¡£
´Ë´Î±¨µÀµÄÑо¿³É¹û£¬ÊÇÕÅÁÖçùºÍÍõÐÂȪÁ½¸ö¿ÎÌâ×é×îеĺÏ×÷²ú³ö¡£ÀûÓýṹÉúÎïѧѧµÄ·½·¨£¬½âÎöÁËRBDÓë¸ßЧµ¥¿Ë¡¿¹ÌåMERS-4¸´ºÏÎïµÄ¾§Ìå½á¹¹£¬½ÒʾÆä¶ÀÌØµÄʶ±ð±íλºÍÖкÍ×÷ÓûúÖÆ¡£ÓëÒѾ±¨µÀµÄ¿¹Ìå±È½Ï£¬MERS-4²¢²»ÊÇÖ±½ÓÓëÊÜÌ徺Õù½áºÏRBD·¢»ÓÆäÖкÍ×÷Ó㬶øÊÇͨ¹ýÓëRBD½áºÏµ¼ÖÂÆäÖÐÒ»¶ÎloopµÄ¹¹Ïó·¢ÉúÁ˽ϴóµÄ±ä»¯£¬½ø¶øÆÆ»µÁËRBDÓëÊÜÌåʶ±ðµÄ¹Ø¼üÇøÓò£¬¼ä½ÓµÄÐÐʹÆä¿¹²¡¶¾¹¦ÄÜ¡£ ´ËÍ⣬MERS-4¶Àµ½µÄʶ±ð±íλºÍÖкͻúÖÆÊ¹ËüÄܹ»ÓëÆäËü¿¹MERS-CoV¿¹Ìå²úÉúÐͬ×÷Óã¬Ìá¸ß¿¹²¡¶¾»îÐԺ͹ãÆ×ÐÔ£¬ÕâΪ¿¹ÌåÒ©ÎïÑз¢ÌṩÁËȫеÄÑ¡Ôñ¡£
¸ÃÑо¿µÄͨѶ×÷ÕßΪ1xbetÍøÒ³°æÕÅÁÖçù½ÌÊÚºÍÉúÃü¿ÆÑ§Ñ§ÔºÍõÐÂȪ½ÌÊÚ£¬ÉúÃü¿ÆÑ§Ñ§Ôº²©Ê¿ÉúÕÅÉÑà¡¢1xbetÍøÒ³°æ²©Ê¿ÉúÖÜÅÎÅκÍÉúÃü¿ÆÑ§Ñ§Ôº²©Ê¿ÉúÍõÅô·ÉΪ¹²Í¬µÚÒ»×÷Õß¡£¸ÃÑо¿µÃµ½Á˹ú¼Ò×ÔÈ»¿ÆÑ§»ù½ð¡¢¿Æ¼¼²¿ÖصãÑз¢ÏîÄ¿¡¢±È¶û¼°Ã·ÁÕ´ï¸Ç´Ä»ù½ðµÈµÄ×ÊÖú¡£
MERS-4ÓëRBD¸´ºÏÎï½á¹¹
¡òÂÛÎÄÁ´½Ó£º
https://www.cell.com/cell-reports/fulltext/S2211-1247(18)30951-3
ÉÏÒ»Ìõ£º1xbetÍøÒ³°æÁκé¶÷ÍŶÓÔÚÈ˹¤ÖÇÄÜÍÚ¾òÓ°Ïñ»ùÒò×éѧÁìÓòºÏ×÷³É¹û·¢±íϵÁÐÂÛÎÄ£¬½Ó¹ì...