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Tsinghua Professor Kehkooi Kee group collaborates to reveal single-cell dual-omics transcriptome and translatome during human oocyte maturation

Jie Na’s group reports the role of JUNB in the differentiation of hematopoietic progenitor cells in vitro through multi-omics analysisJie Na’s group reports the role of JUNB in the differentiation of hematopoietic progenitor cells in vitro through multi-o

Zheng Lab reports new mechanism of breast cancer immune evasion

Jing-Ren Zhang’s group published research article to reveal the novel mechanism of immune evasion to liver macrophages by bacterial capsules in sepsis

A new rapid lung-cancer drug sensitivity test

Mammalian oocyte maturation is a special biological process in which gene transcription is arrested, and mainly regulated by gene translation. At present, most of the omics studies on oocyte maturation are based on the transcriptional expression level, which cannot accurately reflect the translational expression level of genes. Moreover, profiling of translatome requires a large number of cells...

Hematopoietic stem cells (HSC) reside in the bone marrow and possess the ability to self-renewal and differentiate into all blood cell types; therefore hold great potential in cell-based therapies and regenerative medicine. In 2019, Zeng et al. reported the single-cell map of hematopoietic stem cells (HSCs) generated in the human embryo (Zeng et al., 2019). However, due to the inaccessibility o...

Breast cancer is one of the leading causes of cancer-related mortality in women.Immunotherapy, especially immune checkpoint inhibitors (ICIs), including PD-1, PD-L1 and CTLA-4 blocking antibodies, has generated remarkable responses in many individuals with solid tumors. However, in breast cancer, especially triple-negative breast cancer (TNBC), limited patients benefit from ICI therapy, indicat...

Prof. Jing-Ren Zhang’s group at Center for Infectious Disease Research, School of Medicine, Tsinghua University published research article on March 9, 2022 in Journal of Experimental Medicine entitled “Functional vulnerability of liver macrophages to capsules defines virulence of blood-borne bacteria”. This work demonstrated how the capsules enable bacterial pathogens to circumvent molecula...

Editor’s noteEarly diagnosis can make a world of difference for cancer patients. This is particularly true for patients with lung cancer as the disease is usually diagnosed in a late stage when it might be already too late.To improve the early diagnosis and treatment of lung cancer, Tsinghua’s Professor Peng Liu and his team have come up with a new drug sensitivity testing system that can pro...

Collaborative research carried out by researchers from the School of Medicine, Tsinghua University, and Cambridge University, United Kingdom, set up machine learning-assisted high-content image analysis to study pluripotent stem cell-derived embryos in vitro. The study enabled automated and high-throughput analysis of stem cell-based embryo models. Stem cell-based embryo models synthesized b...

Dr. Jie Na’s group generated a MESP1 cardiovascular progenitor reporter cell line to facilitate highly efficient cardiomyocyte, endothelial cells and vascular smooth muscle cells differentiation and heart repair

What if metal was more than just a cold and rigid material?Although T-1000, the self-repairing, shape-shifting android assassin was merely a figment of creative imagination, the vision is a step close...

It is a common belief that working out regularly will not only keep us fit, but also strengthen our immune system. However, it also turns out that after running a marathon it is easier to catch a cold...

Prof. Zhang Linqi from the School of Medicine finds powerful antibody for SARS-CoV-2